We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
- Authors
Irandoust, Mahban; Alvarez Zarate, Julian; Hubeek, Isabelle; van Beek, Ellen M; Schornagel, Karin; Broekhuizen, Aart J F; Akyuz, Mercan; van de Loosdrecht, Arjan A; Delwel, Ruud; Valk, Peter J; Sonneveld, Edwin; Kearns, Pamela; Creutzig, Ursula; Reinhardt, Dirk; de Bont, Eveline S J M; Coenen, Eva A; van den Heuvel-Eibrink, Marry M; Zwaan, C Michel; Kaspers, Gertjan J L; Cloos, Jacqueline; van den Berg, Timo K
- Abstract
Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.
- Publication
PloS one, 2013, Vol 8, Issue 1, pe52143
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0052143