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- Title
Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways.
- Authors
Dayyani, Farshid; Parikh, Nila U; Varkaris, Andreas S; Song, Jian H; Moorthy, Shhyam; Chatterji, Tanushree; Maity, Sankar N; Wolfe, Adam R; Carboni, Joan M; Gottardis, Marco M; Logothetis, Christopher J; Gallick, Gary E
- Abstract
Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa results in improved tumor inhibition. The Src family kinases (SFK) and insulin-like growth factor-1 (IGF-1) signaling axes are aberrantly activated in both primary PCa and bone metastases and regulate distinct and overlapping functions in PCa progression. We examined the antitumor effects of combined inhibition of these pathways.
- Publication
PloS one, 2012, Vol 7, Issue 12, pe51189
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0051189