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- Title
Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats.
- Authors
Hu, Guo-Xin; Lin, Han; Lian, Qing-Quan; Zhou, Shu-Hua; Guo, Jingjing; Zhou, Hong-Yu; Chu, Yanhui; Ge, Ren-Shan
- Abstract
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoid locally in liver and fat tissues to aggravate metabolic syndrome. 11β-HSD1 selective inhibitor can be used to treat metabolic syndrome. Curcumin and its derivatives as selective inhibitors of 11β-HSD1 have not been reported.
- Publication
PloS one, 2013, Vol 8, Issue 3, pe49976
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0049976