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- Title
Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae.
- Authors
Leijten, Jeroen C H; Moreira Teixeira, Liliana S; Landman, Ellie B M; van Blitterswijk, Clemens A; Karperien, Marcel
- Abstract
Hypertrophic differentiation of growth plate chondrocytes induces angiogenesis which alleviates hypoxia normally present in cartilage. In the current study, we aim to determine whether alleviation of hypoxia is merely a downstream effect of hypertrophic differentiation as previously described or whether alleviation of hypoxia and consequent changes in oxygen tension mediated signaling events also plays an active role in regulating the hypertrophic differentiation process itself.
- Publication
PloS one, 2012, Vol 7, Issue 11, pe49896
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0049896