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- Title
Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
- Authors
van Vuuren, Stefan H; Sol, Chalana M; Broekhuizen, Roel; Lilien, Marc R; Oosterveld, Michiel J S; Nguyen, Tri Q; Goldschmeding, Roel; de Jong, Tom P V M
- Abstract
Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephron hypertrophy is unresolved. This question is of utmost clinical importance, since hypertrophy is associated with a risk of developing hypertension and proteinuria later in life with consequent development of CKD and cardiovascular disease.
- Publication
PloS one, 2012, Vol 7, Issue 11, pe49735
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0049735