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- Title
Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade.
- Authors
Rossaint, Jan; Berger, Christian; Van Aken, Hugo; Scheld, Hans H; Zahn, Peter K; Rukosujew, Andreas; Zarbock, Alexander
- Abstract
It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like fashion, including capturing, rolling, adhesion, and transmigration. However, the molecular mechanisms of increased leukocyte recruitment caused by CPB are not known. This clinical study was undertaken in order to investigate which steps of the leukocyte recruitment cascade are affected by the systemic inflammation during CPB.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe45738
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0045738