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- Title
The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
- Authors
Wiggs, Janey L; Hewitt, Alex W; Fan, Bao Jian; Wang, Dan Yi; Figueiredo Sena, Dayse R; O'Brien, Colm; Realini, Anthony; Craig, Jamie E; Dimasi, David P; Mackey, David A; Haines, Jonathan L; Pasquale, Louis R
- Abstract
Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe45613
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0045613