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- Title
WaveSeq: a novel data-driven method of detecting histone modification enrichments using wavelets.
- Authors
Mitra, Apratim; Song, Jiuzhou
- Abstract
Chromatin immunoprecipitation followed by next-generation sequencing is a genome-wide analysis technique that can be used to detect various epigenetic phenomena such as, transcription factor binding sites and histone modifications. Histone modification profiles can be either punctate or diffuse which makes it difficult to distinguish regions of enrichment from background noise. With the discovery of histone marks having a wide variety of enrichment patterns, there is an urgent need for analysis methods that are robust to various data characteristics and capable of detecting a broad range of enrichment patterns.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe45486
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0045486