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- Title
Elevated serum ferritin is associated with reduced survival in amyotrophic lateral sclerosis.
- Authors
Nadjar, Yann; Gordon, Paul; Corcia, Philippe; Bensimon, Gilbert; Pieroni, Laurence; Meininger, Vincent; Salachas, François
- Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by the loss of motor neurons. Its etiology remains unknown, but several hypothesis have been raised to explain motor neuron death, including oxidative stress. Dysregulation of cellular iron metabolism can lead to increased oxidative stress, and existing data argue for a role of iron metabolism in ALS pathophysiology.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe45034
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0045034