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- Title
Neutrophils are not less sensitive than other blood leukocytes to the genomic effects of glucocorticoids.
- Authors
Hirsch, Gaelle; Lavoie-Lamoureux, Anouk; Beauchamp, Guy; Lavoie, Jean-Pierre
- Abstract
Neutrophils are generally considered less responsive to glucocorticoids compared to other inflammatory cells. The reported increase in human neutrophil survival mediated by these drugs partly supports this assertion. However, it was recently shown that dexamethasone exerts potent anti-inflammatory effects in equine peripheral blood neutrophils. Few comparative studies of glucocorticoid effects in neutrophils and other leukocytes have been reported and a relative insensitivity of neutrophils to these drugs could not be ruled out.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe44606
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0044606