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- Title
Monitoring CSF proteome alterations in amyotrophic lateral sclerosis: obstacles and perspectives in translating a novel marker panel to the clinic.
- Authors
von Neuhoff, Nils; Oumeraci, Tonio; Wolf, Thomas; Kollewe, Katja; Bewerunge, Peter; Neumann, Boris; Brors, Benedikt; Bufler, Johannes; Wurster, Ulrich; Schlegelberger, Brigitte; Dengler, Reinhard; Zapatka, Marc; Petri, Susanne
- Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal disorder of the motor neuron system with poor prognosis and marginal therapeutic options. Current clinical diagnostic criteria are based on electrophysiological examination and exclusion of other ALS-mimicking conditions. Neuroprotective treatments are, however, most promising in early disease stages. Identification of disease-specific CSF biomarkers and associated biochemical pathways is therefore most relevant to monitor disease progression, response to neuroprotective agents and to enable early inclusion of patients into clinical trials.
- Publication
PloS one, 2012, Vol 7, Issue 9, pe44401
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0044401