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- Title
CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice.
- Authors
Johannesson, Bjarki; Hirtz, Stephanie; Schatterny, Jolanthe; Schultz, Carsten; Mall, Marcus A
- Abstract
Factors determining the onset and severity of chronic obstructive pulmonary disease remain poorly understood. Previous studies demonstrated that airway surface dehydration in βENaC-overexpressing (βENaC-Tg) mice on a mixed genetic background caused either neonatal mortality or chronic obstructive lung disease suggesting that the onset of lung disease was modulated by the genetic background.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe44059
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0044059