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- Title
A case-control study of peripheral blood mitochondrial DNA copy number and risk of renal cell carcinoma.
- Authors
Purdue, Mark P; Hofmann, Jonathan N; Colt, Joanne S; Hoxha, Mirjam; Ruterbusch, Julie J; Davis, Faith G; Rothman, Nathaniel; Wacholder, Sholom; Schwartz, Kendra L; Baccarelli, Andrea; Chow, Wong-Ho
- Abstract
Low mitochondrial DNA (mtDNA) copy number is a common feature of renal cell carcinoma (RCC), and may influence tumor development. Results from a recent case-control study suggest that low mtDNA copy number in peripheral blood may be a marker for increased RCC risk. In an attempt to replicate that finding, we measured mtDNA copy number in peripheral blood DNA from a U.S. population-based case-control study of RCC.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe43149
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0043149