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- Title
Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.
- Authors
Boudou-Rouquette, Pascaline; Narjoz, Céline; Golmard, Jean Louis; Thomas-Schoemann, Audrey; Mir, Olivier; Taieb, Fabrice; Durand, Jean-Philippe; Coriat, Romain; Dauphin, Alain; Vidal, Michel; Tod, Michel; Loriot, Marie-Anne; Goldwasser, François; Blanchet, Benoit
- Abstract
Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study was to investigate the relationship between early toxicity and drug exposure or pharmacogenetic variants in unselected adult outpatients treated with single-agent sorafenib for advanced solid tumors.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe42875
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0042875