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- Title
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
- Authors
Bozdagi, Ozlem; Sakurai, Takeshi; Dorr, Nathan; Pilorge, Marion; Takahashi, Nagahide; Buxbaum, Joseph D
- Abstract
Copy number variation (CNV) at the 15q11.2 region, which includes a gene that codes for CYFIP1 (cytoplasmic FMR1 interacting protein 1), has been implicated in autism, intellectual disability and additional neuropsychiatric phenotypes. In the current study we studied the function of Cyfip1 in synaptic physiology and behavior, using mice with a disruption of the Cyfip1 gene.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe42422
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0042422