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- Title
Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.
- Authors
Mulvihill, Michael S; Kwon, Yong-Won; Lee, Sharon; Fang, Li Tai; Choi, Helen; Ray, Roshni; Kang, Hio Chung; Mao, Jian-Hua; Jablons, David; Kim, Il-Jin
- Abstract
Gremlin, a member of the Dan family of BMP antagonists, is a glycosylated extracellular protein. Previously Gremlin has been shown to play a role in dorsal-ventral patterning, in tissue remodeling, and recently in angiogenesis. Evidence has previously been presented showing both over- and under-expression of Gremlin in different tumor tissues. Here, we sought to quantify expression of Gremlin in cancers of the lung and performed in vitro experiments to check whether Gremlin promotes cell growth and proliferation.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe42264
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0042264