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- Title
A surgical model of permanent and transient middle cerebral artery stroke in the sheep.
- Authors
Wells, Adam J; Vink, Robert; Blumbergs, Peter C; Brophy, Brian P; Helps, Stephen C; Knox, Steven J; Turner, Renée J
- Abstract
Animal models are essential to study the pathophysiological changes associated with focal occlusive stroke and to investigate novel therapies. Currently used rodent models have yielded little clinical success, however large animal models may provide a more suitable alternative to improve clinical translation. We sought to develop a model of acute proximal middle cerebral artery (MCA) ischemic stroke in sheep, including both permanent occlusion and transient occlusion with reperfusion.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe42157
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0042157