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- Title
HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice.
- Authors
Ishiwata, Takahiro; Orosz, András; Wang, Xiaohui; Mustafi, Soumyajit Banerjee; Pratt, Gregory W; Christians, Elisabeth S; Boudina, Sihem; Abel, E Dale; Benjamin, Ivor J
- Abstract
CryAB (HspB5) and HspB2, two small heat shock genes located adjacently in the vertebrate genome, are hypothesized to play distinct roles. Mice lacking both cryab and hspb2 (DKO) are viable and exhibit adult-onset degeneration of skeletal muscle but confounding results from independent groups were reported for cardiac responses to different stressful conditions (i.e., ischemia/reperfusion or pressure overload). To determine the specific requirements of HSPB2 in heart, we generated cardiac-specific HSPB2 deficient (HSPB2cKO) mice and examined their cardiac function under basal conditions and following cardiac pressure overload.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe42118
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0042118