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- Title
Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.
- Authors
Kitada, Kento; Nakano, Daisuke; Liu, Ya; Fujisawa, Yoshihide; Hitomi, Hirofumi; Shibayama, Yuki; Shibata, Hirotaka; Nagai, Yukiko; Mori, Hirohito; Masaki, Tsutomu; Kobori, Hiroyuki; Nishiyama, Akira
- Abstract
Mineralocorticoid receptor (MR) antagonists attenuate renal injury in salt-sensitive hypertensive rats with low plasma aldosterone levels. We hypothesized that oxidative stress causes MR activation in high-salt-fed Dahl salt-sensitive rats. Furthermore, we determined if MR activation persisted and induced renal injury, even after switching from a high- to a normal-salt diet.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41896
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041896