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- Title
Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.
- Authors
Nobili, Elena; Salvado, M Dolores; Folkersen, Lasse; Castiglioni, Laura; Kastrup, Jens; Wetterholm, Anders; Tremoli, Elena; Hansson, Göran K; Sironi, Luigi; Haeggström, Jesper Z; Gabrielsen, Anders
- Abstract
Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcirculation and its response to hypoxic stress. To this end, we examined Apoe(-/-) mice fed a hypercholesterolemic diet and analysed the expression of key enzymes of the cys-LT pathway and their receptors (CysLT1/CysLT2) in normal and hypoxic myocardium as well as the potential contribution of cys-LT signaling to the acute myocardial response to hypoxia.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41786
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041786