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- Title
Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA.
- Authors
Almgren, Malin; Atkinson, Richard; He, Jia; Hilding, Agneta; Hagman, Emilia; Wolk, Alicja; Thorell, Anders; Marcus, Claude; Näslund, Erik; Östenson, Claes-Göran; Schalling, Martin; Lavebratt, Catharina
- Abstract
Experimental and natural human adenovirus-36 (Adv36) infection of multiple animal species results in obesity through increasing adipogenesis and lipid accumulation in adipocytes. Presence of Adv36 antibodies detected by serum neutralization assay has previously been associated with obesity in children and adults living in the USA, South Korea and Italy, whereas no association with adult obesity was detected in Belgium/The Netherlands nor among USA military personnel. Adv36 infection has also been shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41652
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041652