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- Title
Molecular evolution of GII-4 Norovirus strains.
- Authors
Zakikhany, Katherina; Allen, David J; Brown, David; Iturriza-Gómara, Miren
- Abstract
Human Noroviruses (NoV) are the major cause of acute nonbacterial gastroenteritis and the leading cause of outbreaks of gastroenteritis worldwide. Genotype II-4 (GII-4) NoV has been shown to spread rapidly and is the most commonly detected strain worldwide, particularly in association with outbreaks. Previously, we have shown that circulating GII-4 NoV strains exist as populations of selectively neutral variants, and that the emergence of epidemic GII-4 NoV strains correlated with mutations in at least two key sites (Sites A and B) within the P2 domain of the surface exposed major capsid protein (VP1).
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41625
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041625