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- Title
The potential of avian H1N1 influenza A viruses to replicate and cause disease in mammalian models.
- Authors
Koçer, Zeynep A; Krauss, Scott; Stallknecht, David E; Rehg, Jerold E; Webster, Robert G
- Abstract
H1N1 viruses in which all gene segments are of avian origin are the most frequent cause of influenza pandemics in humans; therefore, we examined the disease-causing potential of 31 avian H1N1 isolates of American lineage in DBA/2J mice. Thirty of 31 isolates were very virulent, causing respiratory tract infection; 22 of 31 resulted in fecal shedding; and 10 of 31 were as pathogenic as the pandemic 2009 H1N1 viruses. Preliminary studies in BALB/cJ mice and ferrets showed that 1 of 4 isolates tested was more pathogenic than the pandemic 2009 H1N1 viruses in BALB/cJ mice, and 1 of 2 strains transmitted both by direct and respiratory-droplet contact in ferrets. Preliminary studies of other avian subtypes (H2, H3, H4, H6, H10, H12) in DBA/2J mice showed lower pathogenicity than the avian H1N1 viruses. These findings suggest that avian H1N1 influenza viruses are unique among influenza A viruses in their potential to infect mammals.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41609
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041609