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- Title
Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography.
- Authors
Karczewski, Peter; Pohlmann, Andreas; Wagenhaus, Babette; Wisbrun, Natali; Hempel, Petra; Lemke, Bernd; Kunze, Rudolf; Niendorf, Thoralf; Bimmler, Marion
- Abstract
Circulating agonistic autoantibodies acting at G protein-coupled receptors have been associated with numerous sever pathologies in humans. Antibodies directed predominantly against the α(1)-adrenergig receptor were detected in patients suffering from widespread diseases such as hypertension and type 2 diabetes. Their deleterious action has been demonstrated for peripheral organs. We postulate that antibodies to the α(1)-adrenergig receptor are relevant pathomolecules in diseases of the central nervous system associated with vascular impairments.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41602
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041602