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Title
Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.
Authors
Chen, Hao; Untiveros, Gustavo M; McKee, Laurel A K; Perez, Jessica; Li, Jing; Antin, Parker B; Konhilas, John P
Abstract
Recently, MicroRNAs (miR) and AMP-kinase (AMPK) have emerged as prominent players in the development of cardiac hypertrophy and heart failure. We hypothesized that components of the adenosine monophosphate-activated kinase (AMPK) pathway are targeted by miRs and alter AMPK signaling during pathological cardiac stress.