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- Title
Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos.
- Authors
Weimar, Charlotte H E; Kavelaars, Annemieke; Brosens, Jan J; Gellersen, Birgit; de Vreeden-Elbertse, Johanna M T; Heijnen, Cobi J; Macklon, Nick S
- Abstract
The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endometrial stromal cells (H-EnSCs) of women with RM discriminate less effectively between high-and low-quality human embryos and migrate more readily towards trophoblast spheroids than H-EnSCs of normally fertile women.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41424
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041424