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- Title
Pre-targeting and direct immunotargeting of liposomal drug carriers to ovarian carcinoma.
- Authors
Lehtinen, Julia; Raki, Mari; Bergström, Kim A; Uutela, Päivi; Lehtinen, Katariina; Hiltunen, Annukka; Pikkarainen, Jere; Liang, Huamin; Pitkänen, Sari; Määttä, Ann-Marie; Ketola, Raimo A; Yliperttula, Marjo; Wirth, Thomas; Urtti, Arto
- Abstract
Epidermal growth factor receptor (EGFR) is overexpressed in many solid tumor types, such as ovarian carcinoma. Immunoliposome based drug targeting has shown promising results in drug delivery to the tumors. However, the ratio of tumor-to-normal tissue concentrations should be increased to minimize the adverse effects of cytostatic drugs.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe41410
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041410