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- Title
Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection.
- Authors
Ormsby, Christopher E; Sengupta, Devi; Tandon, Ravi; Deeks, Steven G; Martin, Jeffrey N; Jones, R Brad; Ostrowski, Mario A; Garrison, Keith E; Vázquez-Pérez, Joel A; Reyes-Terán, Gustavo; Nixon, Douglas F
- Abstract
Human endogenous retroviruses (HERV) are remnants of ancestral retroviral infections integrated into the germ line, and constitute approximately 8% of the genome. Several autoimmune disorders, malignancies, and infectious diseases such as HIV-1 are associated with higher HERV expression. The degree to which HERV expression in vivo results in persistent inflammation is not known. We studied the association of immune activation and HERV-K expression in 20 subjects with chronic, untreated progressive HIV-1 infection and 10 HIV-1 negative controls. The mean HERV-K gag and env RNA expression level in the HIV-1 infected cohort was higher than in the control group (p = 0.0003), and was negatively correlated with the frequency of activated CD38+HLA-DR+CD4+ T cells (Rho = -0.61; p = 0.01) and activated CD38+HLA-DR+CD8+ T cells (Rho = -0.51; p = 0.03). Although HIV-infected persons had higher levels of HERV-K RNA expression (as expected), the level of RNA expression was negatively associated with level of T cell activation. The mechanism for this unexpected association remains to be defined.
- Publication
PloS one, 2012, Vol 7, Issue 8, pe41021
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0041021