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- Title
A comparison of gene region simulation methods.
- Authors
Hendricks, Audrey E; Dupuis, Josée; Gupta, Mayetri; Logue, Mark W; Lunetta, Kathryn L
- Abstract
Accurately modeling LD in simulations is essential to correctly evaluate new and existing association methods. At present, there has been minimal research comparing the quality of existing gene region simulation methods to produce LD structures similar to an existing gene region. Here we compare the ability of three approaches to accurately simulate the LD within a gene region: HapSim (2005), Hapgen (2009), and a minor extension to simple haplotype resampling.
- Publication
PloS one, 2012, Vol 7, Issue 7, pe40925
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0040925