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- Title
Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.
- Authors
Aldrich, Melinda C; Kumar, Rajesh; Colangelo, Laura A; Williams, L Keoki; Sen, Saunak; Kritchevsky, Stephen B; Meibohm, Bernd; Galanter, Joshua; Hu, Donglei; Gignoux, Christopher R; Liu, Yongmei; Harris, Tamara B; Ziv, Elad; Zmuda, Joseph; Garcia, Melissa; Leak, Tennille S; Foreman, Marilyn G; Smith, Lewis J; Fornage, Myriam; Liu, Kiang; Burchard, Esteban G; Health ABC and CARDIA Studies Groups
- Abstract
Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans.
- Publication
PloS one, 2012, Vol 7, Issue 6, pe39541
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0039541