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- Title
Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling.
- Authors
Björkgren, Ida; Saastamoinen, Lauri; Krutskikh, Anton; Huhtaniemi, Ilpo; Poutanen, Matti; Sipilä, Petra
- Abstract
The postnatal development of the epididymis is a complex process that results in a highly differentiated epithelium, divided into several segments. Recent studies indicate a role for RNA interference (RNAi) in the development of the epididymis, however, the actual requirement for RNAi has remained elusive. Here, we present the first evidence of a direct need for RNAi in the differentiation of the epididymal epithelium.
- Publication
PloS one, 2012, Vol 7, Issue 6, pe38457
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0038457