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- Title
Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice.
- Authors
Azibani, Feriel; Devaux, Yvan; Coutance, Guillaume; Schlossarek, Saskia; Polidano, Evelyne; Fazal, Loubina; Merval, Regine; Carrier, Lucie; Solal, Alain Cohen; Chatziantoniou, Christos; Launay, Jean-Marie; Samuel, Jane-Lise; Delcayre, Claude
- Abstract
Arterial hypertension (AH) induces cardiac hypertrophy and reactivation of "fetal" gene expression. In rodent heart, alpha-Myosin Heavy Chain (MyHC) and its micro-RNA miR-208a regulate the expression of beta-MyHC and of its intronic miR-208b. However, the role of aldosterone in these processes remains unclear.
- Publication
PloS one, 2012, Vol 7, Issue 5, pe38197
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0038197