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- Title
DISCO-SCA and properly applied GSVD as swinging methods to find common and distinctive processes.
- Authors
Van Deun, Katrijn; Van Mechelen, Iven; Thorrez, Lieven; Schouteden, Martijn; De Moor, Bart; van der Werf, Mariët J; De Lathauwer, Lieven; Smilde, Age K; Kiers, Henk A L
- Abstract
In systems biology it is common to obtain for the same set of biological entities information from multiple sources. Examples include expression data for the same set of orthologous genes screened in different organisms and data on the same set of culture samples obtained with different high-throughput techniques. A major challenge is to find the important biological processes underlying the data and to disentangle therein processes common to all data sources and processes distinctive for a specific source. Recently, two promising simultaneous data integration methods have been proposed to attain this goal, namely generalized singular value decomposition (GSVD) and simultaneous component analysis with rotation to common and distinctive components (DISCO-SCA).
- Publication
PloS one, 2012, Vol 7, Issue 5, pe37840
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0037840