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- Title
Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection.
- Authors
Curriu, Marta; Carrillo, Jorge; Massanella, Marta; Garcia, Elisabet; Cunyat, Francesc; Peña, Ruth; Wienberg, Peter; Carrato, Cristina; Areal, Joan; Bofill, Margarita; Clotet, Bonaventura; Blanco, Julià; Cabrera, Cecilia
- Abstract
Xenotropic murine leukemia virus-related virus (XMRV) was generated after a recombination event between two endogenous murine leukemia viruses during the production of a prostate cancer cell line. Although the associations of the XMRV infection with human diseases appear unlikely, the XMRV is a retrovirus of undefined pathogenic potential, able to replicate in human cells in vitro. Since recent studies using animal models for infection have yielded conflicting results, we set out an ex vivo model for XMRV infection of human tonsillar tissue to determine whether XMRV produced by 22Rv1 cells is able to replicate in human lymphoid organs. Tonsil blocks were infected and infection kinetics and its pathogenic effects were monitored
- Publication
PloS one, 2012, Vol 7, Issue 5, pe37415
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0037415