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- Title
Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age.
- Authors
Andersen, Helle R; Wohlfahrt-Veje, Christine; Dalgård, Christine; Christiansen, Lene; Main, Katharina M; Nellemann, Christine; Murata, Katsuyuki; Jensen, Tina K; Skakkebæk, Niels E; Grandjean, Philippe
- Abstract
Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.
- Publication
PloS one, 2012, Vol 7, Issue 5, pe36830
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0036830