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- Title
Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.
- Authors
Drannik, Anna G; Nag, Kakon; Yao, Xiao-Dan; Henrick, Bethany M; Sallenave, Jean-Michel; Rosenthal, Kenneth L
- Abstract
Upon viral recognition, innate and adaptive antiviral immune responses are initiated by genital epithelial cells (ECs) to eradicate or contain viral infection. Such responses, however, are often accompanied by inflammation that contributes to acquisition and progression of sexually transmitted infections (STIs). Hence, interventions/factors enhancing antiviral protection while reducing inflammation may prove beneficial in controlling the spread of STIs. Serine antiprotease trappin-2 (Tr) and its cleaved form, elafin (E), are alarm antimicrobials secreted by multiple cells, including genital epithelia.
- Publication
PloS one, 2012, Vol 7, Issue 4, pe35866
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035866