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- Title
Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.
- Authors
Boutant, Marie; Ramos, Oscar Henrique Pereira; Lecoeur, Cécile; Vaillant, Emmanuel; Philippe, Julien; Zhang, Pili; Perilhou, Anaïs; Valcarcel, Beatriz; Sebert, Sylvain; Jarvelin, Mario-Ritta; Balkau, Beverley; Scott, Donald; Froguel, Philippe; Vaxillaire, Martine; Vasseur-Cognet, Mireille
- Abstract
The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown and its influence on metabolism in humans is poorly understood. The present study aimed to identify the regulatory regions that control NR2F2 gene transcription and to evaluate the effect of NR2F2 promoter variation on glucose homeostasis in humans.
- Publication
PloS one, 2012, Vol 7, Issue 5, pe35810
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035810