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- Title
Differential evolutionary wiring of the tyrosine kinase Btk.
- Authors
Nawaz, Hossain M; Kylsten, Per; Hamada, Noriko; Yamamoto, Daisuke; Smith, C I Edvard; Lindvall, Jessica M
- Abstract
A central question within biology is how intracellular signaling pathways are maintained throughout evolution. Btk29A is considered to be the fly-homolog of the mammalian Bruton's tyrosine kinase (Btk), which is a non-receptor tyrosine-kinase of the Tec-family. In mammalian cells, there is a single transcript splice-form and the corresponding Btk-protein plays an important role for B-lymphocyte development with alterations within the human BTK gene causing the immunodeficiency disease X-linked agammaglobulinemia in man and a related disorder in mice. In contrast, the Drosophila Btk29A locus encodes two splice-variants, where the type 2-form is the more related to the mammalian Btk gene product displaying more than 80% homology. In Drosophila, Btk29A displays a dynamic pattern of expression through the embryonic to adult stages. Complete loss-of-function of both splice-forms is lethal, whereas selective absence of the type 2-form reduces the adult lifespan of the fly and causes developmental abnormalities in male genitalia.
- Publication
PloS one, 2012, Vol 7, Issue 5, pe35640
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035640