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- Title
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.
- Authors
Lovly, Christine M; Dahlman, Kimberly Brown; Fohn, Laurel E; Su, Zengliu; Dias-Santagata, Dora; Hicks, Donna J; Hucks, Donald; Berry, Elizabeth; Terry, Charles; Duke, MarKeesa; Su, Yingjun; Sobolik-Delmaire, Tammy; Richmond, Ann; Kelley, Mark C; Vnencak-Jones, Cindy L; Iafrate, A John; Sosman, Jeffrey; Pao, William
- Abstract
Knowledge of tumor mutation status is becoming increasingly important for the treatment of cancer, as mutation-specific inhibitors are being developed for clinical use that target only sub-populations of patients with particular tumor genotypes. Melanoma provides a recent example of this paradigm. We report here development, validation, and implementation of an assay designed to simultaneously detect 43 common somatic point mutations in 6 genes (BRAF, NRAS, KIT, GNAQ, GNA11, and CTNNB1) potentially relevant to existing and emerging targeted therapies specifically in melanoma.
- Publication
PloS one, 2012, Vol 7, Issue 4, pe35309
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035309