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- Title
Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial.
- Authors
Fox, Chris; Crugel, Monica; Maidment, Ian; Auestad, Bjorn Henrik; Coulton, Simon; Treloar, Adrian; Ballard, Clive; Boustani, Malaz; Katona, Cornelius; Livingston, Gill
- Abstract
Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD.
- Publication
PloS one, 2012, Vol 7, Issue 5, pe35185
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035185