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- Title
Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.
- Authors
Liberman, Ana C; Antunica-Noguerol, Maria; Ferraz-de-Paula, Viviane; Palermo-Neto, Joao; Castro, Carla N; Druker, Jimena; Holsboer, Florian; Perone, Marcelo J; Gerlo, Sarah; De Bosscher, Karolien; Haegeman, Guy; Arzt, Eduardo
- Abstract
Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating proinflammatory gene expression. By favouring GR monomer formation, CpdA does not enhance glucocorticoid (GC) response element-driven gene expression, resulting in a reduced side effect profile as compared to GCs. Considering the importance of Th1/Th2 balance in the final outcome of immune and inflammatory responses, we analyzed how selective GR modulation differentially regulates the activity of T-bet and GATA-3, master drivers of Th1 and Th2 differentiation, respectively.
- Publication
PloS one, 2012, Vol 7, Issue 4, pe35155
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0035155