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- Title
Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction.
- Authors
Mohan, Mahesh; Kaushal, Deepak; Aye, Pyone P; Alvarez, Xavier; Veazey, Ronald S; Lackner, Andrew A
- Abstract
The Gastrointestinal (GI) tract is critical to AIDS pathogenesis as it is the primary site for viral transmission and a major site of viral replication and CD4(+) T cell destruction. Consequently GI disease, a major complication of HIV/SIV infection can facilitate translocation of lumenal bacterial products causing localized/systemic immune activation leading to AIDS progression.
- Publication
PloS one, 2012, Vol 7, Issue 4, pe34561
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0034561