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- Title
Global methylation patterns in idiopathic pulmonary fibrosis.
- Authors
Rabinovich, Einat I; Kapetanaki, Maria G; Steinfeld, Israel; Gibson, Kevin F; Pandit, Kusum V; Yu, Guoying; Yakhini, Zohar; Kaminski, Naftali
- Abstract
Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling. The role of epigenetic changes in determining the lung phenotype in IPF is unknown. In this study we determine whether IPF lungs exhibit an altered global methylation profile.
- Publication
PloS one, 2012, Vol 7, Issue 4, pe33770
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0033770