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- Title
Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma.
- Authors
Navarro, Antonia; Yin, Ping; Monsivais, Diana; Lin, Simon M; Du, Pan; Wei, Jian-Jun; Bulun, Serdar E
- Abstract
Uterine leiomyomas, or fibroids, represent the most common benign tumor of the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to 70% of African American women of reproductive age. Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities remains unknown.
- Publication
PloS one, 2012, Vol 7, Issue 3, pe33284
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0033284