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- Title
Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.
- Authors
Yakub, Mohsin; Moti, Naushad; Parveen, Siddiqa; Chaudhry, Bushra; Azam, Iqbal; Iqbal, Mohammad Perwaiz
- Abstract
Hyperhomocysteinemia (>15 µmol/L) is highly prevalent in South Asian populations including Pakistan. In order to investigate the genetic determinants of this condition, we studied 6 polymorphisms in genes of 3 enzymes--methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C), methionine synthase (MS; A2756G), cystathionine-β-synthase (CBS; T833C/844ins68, G919A) involved in homocysteine metabolism and investigated their interactions with nutritional and environmental factors in a Pakistani population.
- Publication
PloS one, 2012, Vol 7, Issue 3, pe33222
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0033222