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- Title
Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature.
- Authors
Swindell, William R; Johnston, Andrew; Sun, Liou; Xing, Xianying; Fisher, Gary J; Bulyk, Martha L; Elder, James T; Gudjonsson, Johann E
- Abstract
Skin aging is associated with intrinsic processes that compromise the structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain.
- Publication
PloS one, 2012, Vol 7, Issue 3, pe33204
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0033204