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- Title
Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model.
- Authors
Banerjee, Ena Ray; Laflamme, Michael A; Papayannopoulou, Thalia; Kahn, Michael; Murry, Charles E; Henderson, William R, Jr
- Abstract
Our aim was to differentiate human (h) embryonic stem (ES) cells into lung epithelial lineage-specific cells [i.e., alveolar epithelial type I (AEI) and type II (AEII) cells and Clara cells] as the first step in the development of cell-based strategies to repair lung injury in the bleomycin mouse model of idiopathic pulmonary fibrosis (IPF). A heterogeneous population of non-ciliated lung lineage-specific cells was derived by a novel method of embryoid body (EB) differentiation. This differentiated human cell population was used to modulate the profibrotic phenotype in transplanted animals.
- Publication
PloS one, 2012, Vol 7, Issue 3, pe33165
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0033165