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- Title
The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.
- Authors
Urbanek, Margrit; Hayes, M Geoffrey; Lee, Hoon; Freathy, Rachel M; Lowe, Lynn P; Ackerman, Christine; Jafari, Nadereh; Dyer, Alan R; Cox, Nancy J; Dunger, David B; Hattersley, Andrew T; Metzger, Boyd E; Lowe, William L, Jr
- Abstract
Since mediators of inflammation are associated with insulin resistance, and the risk of developing diabetes mellitus and gestational diabetes, we hypothesized that genetic variation in members of the inflammatory gene pathway impact glucose levels and related phenotypes in pregnancy. We evaluated this hypothesis by testing for association between genetic variants in 31 inflammatory pathway genes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort, a large multiethnic multicenter study designed to address the impact of glycemia less than overt diabetes on pregnancy outcome.
- Publication
PloS one, 2012, Vol 7, Issue 3, pe32958
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0032958