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- Title
Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.
- Authors
Padhi, Aditya K; Kumar, Hirdesh; Vasaikar, Suhas V; Jayaram, Bhyravabhotla; Gomes, James
- Abstract
Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD) simulations of wild-type ANG and disease associated ANG variants to elucidate the mechanism behind the loss of ribonucleolytic activity and nuclear translocation activity, functions needed for angiogenesis.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe32479
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0032479