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- Title
MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors.
- Authors
Jiao, Long R; Frampton, Adam E; Jacob, Jimmy; Pellegrino, Loredana; Krell, Jonathan; Giamas, Georgios; Tsim, Nicole; Vlavianos, Panagiotis; Cohen, Patrizia; Ahmad, Raida; Keller, Andreas; Habib, Nagy A; Stebbing, Justin; Castellano, Leandro
- Abstract
MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with pre-malignant pancreatic tumors. We wished to compare the miRNA expression signatures in pancreatic benign cystic tumors (BCT) of low and high malignant potential with PDAC, in order to identify miRNAs deregulated during PDAC development. The mechanistic consequences of miRNA dysregulation were further evaluated.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe32068
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0032068